Circulatory Failure in Typhoid Fever

c ?.Us Pressure with consequent decrease in the c lac output, which is further reduced, because of the impairment of contractility of the heart due to typhoid myocarditis. To combat the resultant steep fall of blood pressure the decrease in circulating blood volume provokes constriction of the peripheral arterioles. The cold clammy skin is due, according to Harrison (1939), to diminished blood flow to the skin because of the decline in the cardiac* output and the local vaso-constriction. The grey cyanosis (pallor 'plus cyanosis) proclaims stagnation of blood at the periphery. In the dual failures of typhoid fever and coronary thrombosis (Levine, 1929), the coldness of the skin affords a striking contrast to the high rectal temperature obtainable in these cases. Circulatory collapse in enteric is not to be attributed to vaso-motor